A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model
A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by inactivating mutations in the
or
genes. Heterozygocity induces hyperactivation of mTOR which can be inhibited by mTOR inhibitors, such as...
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A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model
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TN_cdi_doaj_primary_oai_doaj_org_article_586a03b0e6734851afec92d2ab0bc9c8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_586a03b0e6734851afec92d2ab0bc9c8
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ISSN
2040-2392
E-ISSN
2040-2392
DOI
10.1186/s13229-017-0151-y