Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cor...
Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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ATP6AP2 knockout in the renal nephron impairs receptor-mediated endocytosis, increasing urinary albumin and glucose excretion and impairing weight gain. Nonesterified fatty acids (NEFA) in urine are bound to albumin and reabsorbed in the proximal tubule through receptor-mediated endocytosis by the megalin–cubilin complex. We hypothesized that ATP6A...
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Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
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TN_cdi_doaj_primary_oai_doaj_org_article_58751f5b9b01401cad3940214306ac52
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_58751f5b9b01401cad3940214306ac52
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-69749-x
