Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
About this item
Full title
Author / Creator
Novo, David , Heath, Nikki , Mitchell, Louise , Caligiuri, Giuseppina , MacFarlane, Amanda , Reijmer, Dide , Charlton, Laura , Knight, John , Calka, Monika , McGhee, Ewan , Dornier, Emmanuel , Sumpton, David , Mason, Susan , Echard, Arnaud , Klinkert, Kerstin , Secklehner, Judith , Kruiswijk, Flore , Vousden, Karen , Macpherson, Iain R. , Blyth, Karen , Bailey, Peter , Yin, Huabing , Carlin, Leo M. , Morton, Jennifer , Zanivan, Sara and Norman, Jim C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53’s invasive/migratory gain-of-function by increasing RCP-dependent integrin re...
Alternative Titles
Full title
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
Authors, Artists and Contributors
Author / Creator
Heath, Nikki
Mitchell, Louise
Caligiuri, Giuseppina
MacFarlane, Amanda
Reijmer, Dide
Charlton, Laura
Knight, John
Calka, Monika
McGhee, Ewan
Dornier, Emmanuel
Sumpton, David
Mason, Susan
Echard, Arnaud
Klinkert, Kerstin
Secklehner, Judith
Kruiswijk, Flore
Vousden, Karen
Macpherson, Iain R.
Blyth, Karen
Bailey, Peter
Yin, Huabing
Carlin, Leo M.
Morton, Jennifer
Zanivan, Sara
Norman, Jim C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5887f05591104f9e9068f2413b7885fd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5887f05591104f9e9068f2413b7885fd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07339-y
