Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Cancer cells frequently have amplified centrosomes that must be clustered together to form a bipolar mitotic spindle, and targeting centrosome clustering is considered a promising therapeutic strategy. A high-content chemical screen for inhibitors of centrosome clustering identified Stattic, a Stat3 inhibitor. Stat3 depletion and inhibition in canc...
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Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
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TN_cdi_doaj_primary_oai_doaj_org_article_58af0d7ff4e94bbd92f3feae3e7e8595
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_58af0d7ff4e94bbd92f3feae3e7e8595
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15289
