Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
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Author / Creator
Yamaguchi, Toshihiro , Sumida, Tomokazu S. , Nomura, Seitaro , Satoh, Masahiro , Higo, Tomoaki , Ito, Masamichi , Ko, Toshiyuki , Fujita, Kanna , Sweet, Mary E. , Sanbe, Atsushi , Yoshimi, Kenji , Manabe, Ichiro , Sasaoka, Toshikuni , Taylor, Matthew R. G. , Toko, Haruhiro , Takimoto, Eiki , Naito, Atsuhiko T. and Komuro, Issei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhythmia. Comprehensive single-cell resolution analysis identifies the presence of D1R-expressing CMs in both heart failure model mice and in he...
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Full title
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
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TN_cdi_doaj_primary_oai_doaj_org_article_59249ab8e1b144e4814231c3afc24f46
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59249ab8e1b144e4814231c3afc24f46
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18128-x
