Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter
Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
TWIK1 (K2P1.1,
KCNK1
) is a widely expressed pH-gated two-pore domain K
+
channel (K2P) that contributes to cardiac rhythm generation and insulin release from pancreatic beta cells. TWIK1 displays unique properties among K2Ps including low basal activity and inhibition by extracellular protons through incompletely understood mechanisms....
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Full title
Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter
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TN_cdi_doaj_primary_oai_doaj_org_article_599c47909c884ae08079a61dfce3ba56
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_599c47909c884ae08079a61dfce3ba56
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30853-z
