STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing P...
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation
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Author / Creator
Qin, Cheng , Wang, Yuanyang , Zhao, Bangbo , Li, Zeru , Li, Tianyu , Yang, Xiaoying , Zhao, Yutong and Wang, Weibin
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pancreatic cancer remains one of the most lethal diseases with a relatively low 5-year survival rate, and gemcitabine-based chemoresistance occurs constantly. Mitochondria, as the power factory in cancer cells, are involved in the process of chemoresistance. The dynamic balance of mitochondria is under the control of mitophagy. Stomatin-like protei...
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Full title
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation
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TN_cdi_doaj_primary_oai_doaj_org_article_59bca93925ae4fc893775d67e7c3a7a8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59bca93925ae4fc893775d67e7c3a7a8
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-05711-5