Cellular senescence drives age-dependent hepatic steatosis
Cellular senescence drives age-dependent hepatic steatosis
About this item
Full title
Author / Creator
Ogrodnik, Mikolaj , Miwa, Satomi , Tchkonia, Tamar , Tiniakos, Dina , Wilson, Caroline L. , Lahat, Albert , Day, Christoper P. , Burt, Alastair , Palmer, Allyson , Anstee, Quentin M. , Grellscheid, Sushma Nagaraja , Hoeijmakers, Jan H J. , Barnhoorn, Sander , Mann, Derek A. , Bird, Thomas G. , Vermeij, Wilbert P. , Kirkland, James L. , Passos, João F. , von Zglinicki, Thomas and Jurk, Diana
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent...
Alternative Titles
Full title
Cellular senescence drives age-dependent hepatic steatosis
Authors, Artists and Contributors
Author / Creator
Miwa, Satomi
Tchkonia, Tamar
Tiniakos, Dina
Wilson, Caroline L.
Lahat, Albert
Day, Christoper P.
Burt, Alastair
Palmer, Allyson
Anstee, Quentin M.
Grellscheid, Sushma Nagaraja
Hoeijmakers, Jan H J.
Barnhoorn, Sander
Mann, Derek A.
Bird, Thomas G.
Vermeij, Wilbert P.
Kirkland, James L.
Passos, João F.
von Zglinicki, Thomas
Jurk, Diana
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_59da7366bd92469288a45b90a4b396f9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_59da7366bd92469288a45b90a4b396f9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15691
