The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosom...
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
About this item
Full title
Author / Creator
Lambert, Erwan , Saha, Orthis , Soares Landeira, Bruna , Melo de Farias, Ana Raquel , Hermant, Xavier , Carrier, Arnaud , Pelletier, Alexandre , Gadaut, Johanna , Davoine, Lindsay , Dupont, Cloé , Amouyel, Philippe , Bonnefond, Amélie , Lafont, Frank , Abdelfettah, Farida , Verstreken, Patrik , Chapuis, Julien , Barois, Nicolas , Delahaye, Fabien , Dermaut, Bart , Lambert, Jean-Charles , Costa, Marcos R. and Dourlen, Pierre
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
The
Bridging Integrator 1
(
BIN1
) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human
BIN1
isoform1 (BIN1iso1) overexpression, contrary to human
BIN1
isoform8 (BIN1iso8) and human
B...
Alternative Titles
Full title
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
Authors, Artists and Contributors
Author / Creator
Saha, Orthis
Soares Landeira, Bruna
Melo de Farias, Ana Raquel
Hermant, Xavier
Carrier, Arnaud
Pelletier, Alexandre
Gadaut, Johanna
Davoine, Lindsay
Dupont, Cloé
Amouyel, Philippe
Bonnefond, Amélie
Lafont, Frank
Abdelfettah, Farida
Verstreken, Patrik
Chapuis, Julien
Barois, Nicolas
Delahaye, Fabien
Dermaut, Bart
Lambert, Jean-Charles
Costa, Marcos R.
Dourlen, Pierre
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5a00e9ef0aa64aa8b839b112c52f6f26
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a00e9ef0aa64aa8b839b112c52f6f26
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01285-5
