Ctf4 organizes sister replisomes and Pol α into a replication factory
Ctf4 organizes sister replisomes and Pol α into a replication factory
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and one Pol α-primase into a replication factory. In t...
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Ctf4 organizes sister replisomes and Pol α into a replication factory
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TN_cdi_doaj_primary_oai_doaj_org_article_5a463b53e2944cfd8176059ff5dcaff9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a463b53e2944cfd8176059ff5dcaff9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.47405
