Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oroph...
Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer
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Nakagawa, Takuya , Luebeck, Jens , Zhu, Kaiyuan , Lange, Joshua T. , Sasik, Roman , Phillips, Chad , Sadat, Sayed , Javadzadeh, Sara , Yang, Qian , Monther, Abdula , Fassardi, Santiago , Wang, Allen , Pestonjamasp, Kersi , Rosenthal, Brin , Fisch, Kathleen M. , Mischel, Paul , Bafna, Vineet and Califano, Joseph A.
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Extrachromosomal circular DNA (ecDNA) has been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). However, the molecular mechanisms of human-viral hybrid ecDNA (hybrid ecDNA) for carcinogenesis remains elusive. We ch...
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Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_5a47c8868d0a4aec8ecd7f0864171ab6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a47c8868d0a4aec8ecd7f0864171ab6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57447-9
