Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepa...
Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation through its conversion into palmitoyl coenzyme A. Although palmitoylation affects many proteins, its pathophysiological functions are only partially understood. Here we demonstrate that PA acts as a molecular checkpoint of lipid reprogramming in HepG2 and Hep3B c...
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Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_5a6359cf516a44088329f33bc366206a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a6359cf516a44088329f33bc366206a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42170-0
