A simple method for developing lysine targeted covalent protein reagents
A simple method for developing lysine targeted covalent protein reagents
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Peptide-based covalent probes can target shallow protein surfaces not typically addressable using small molecules, yet there is a need for versatile approaches to convert native peptide sequences into covalent binders that can target a broad range of residues. Here we report protein-based thio-methacrylate esters—electrophiles that can be installed...
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A simple method for developing lysine targeted covalent protein reagents
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TN_cdi_doaj_primary_oai_doaj_org_article_5aae5785bf5a4414ad69a7fd79733088
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5aae5785bf5a4414ad69a7fd79733088
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42632-5
