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Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5b06837f8ef2466591810930fcb8fa03

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

About this item

Full title

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-07, Vol.9 (1), p.2757-13, Article 2757

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signalin...

Alternative Titles

Full title

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_5b06837f8ef2466591810930fcb8fa03

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5b06837f8ef2466591810930fcb8fa03

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-05196-3

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