ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction
ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction
About this item
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Author / Creator
He, Xiang , Ma, Shengli , Tian, Yinyin , Wei, Congwen , Zhu, Yongjie , Li, Feng , Zhang, Pingping , Wang, Penghao , Zhang, Yanhong and Zhong, Hui
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Estrogen-related receptor α (ERRα) is a member of the nuclear receptor superfamily controlling energy homeostasis; however, its precise role in regulating antiviral innate immunity remains to be clarified. Here, we showed that ERRα deficiency conferred resistance to viral infection both in vivo and in vitro. Mechanistically, ERRα inhibited the prod...
Alternative Titles
Full title
ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5b27ac2606bf4ecabadd6da33383479c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5b27ac2606bf4ecabadd6da33383479c
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1006347
