CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
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Author / Creator
Xu, Hong , Di Antonio, Marco , McKinney, Steven , Mathew, Veena , Ho, Brandon , O’Neil, Nigel J. , Santos, Nancy Dos , Silvester, Jennifer , Wei, Vivien , Garcia, Jessica , Kabeer, Farhia , Lai, Daniel , Soriano, Priscilla , Banáth, Judit , Chiu, Derek S. , Yap, Damian , Le, Daniel D. , Ye, Frank B. , Zhang, Anni , Thu, Kelsie , Soong, John , Lin, Shu-chuan , Tsai, Angela Hsin Chin , Osako, Tomo , Algara, Teresa , Saunders, Darren N. , Wong, Jason , Xian, Jian , Bally, Marcel B. , Brenton, James D. , Brown, Grant W. , Shah, Sohrab P. , Cescon, David , Mak, Tak W. , Caldas, Carlos , Stirling, Peter C. , Hieter, Phil , Balasubramanian, Shankar and Aparicio, Samuel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect. Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-de...
Alternative Titles
Full title
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Authors, Artists and Contributors
Author / Creator
Di Antonio, Marco
McKinney, Steven
Mathew, Veena
Ho, Brandon
O’Neil, Nigel J.
Santos, Nancy Dos
Silvester, Jennifer
Wei, Vivien
Garcia, Jessica
Kabeer, Farhia
Lai, Daniel
Soriano, Priscilla
Banáth, Judit
Chiu, Derek S.
Yap, Damian
Le, Daniel D.
Ye, Frank B.
Zhang, Anni
Thu, Kelsie
Soong, John
Lin, Shu-chuan
Tsai, Angela Hsin Chin
Osako, Tomo
Algara, Teresa
Saunders, Darren N.
Wong, Jason
Xian, Jian
Bally, Marcel B.
Brenton, James D.
Brown, Grant W.
Shah, Sohrab P.
Cescon, David
Mak, Tak W.
Caldas, Carlos
Stirling, Peter C.
Hieter, Phil
Balasubramanian, Shankar
Aparicio, Samuel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5b722e62084b4032919682ab16257e1a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5b722e62084b4032919682ab16257e1a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14432
