MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
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Author / Creator
Liu, Siqi , Chen, Jueqi , Cai, Xin , Wu, Jiaxi , Chen, Xiang , Wu, You-Tong , Sun, Lijun and Chen, Zhijian J
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferons. Here we show that MAVS polymers recruit several...
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Full title
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
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TN_cdi_doaj_primary_oai_doaj_org_article_5c8d9075c1744f2690767f95ef34cf86
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5c8d9075c1744f2690767f95ef34cf86
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.00785
