MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as bi...
MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires dimerization with MAX to activate transcription of numerous target genes. MYCN gain has been associated with adverse prognosis...
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MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates
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TN_cdi_doaj_primary_oai_doaj_org_article_5c8f2bf2032c400ca1d44e341c610330
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5c8f2bf2032c400ca1d44e341c610330
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ISSN
1475-2867
E-ISSN
1475-2867
DOI
10.1186/s12935-021-02259-2
