An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneum...
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
About this item
Full title
Author / Creator
Patel, Ami , DiGiandomenico, Antonio , Keller, Ashley E. , Smith, Trevor R. F. , Park, Daniel H. , Ramos, Stephanie , Schultheis, Katherine , Elliott, Sarah T. C. , Mendoza, Janess , Broderick, Kate E. , Wise, Megan C. , Yan, Jian , Jiang, Jingjing , Flingai, Seleeke , Khan, Amir S. , Muthumani, Kar , Humeau, Laurent , Cheng, Lily I. , Wachter-Rosati, Leslie , Stover, C. Kendall , Sardesai, Niranjan Y. and Weiner, David B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in vivo, potentially allow the prevention or treatment...
Alternative Titles
Full title
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
Authors, Artists and Contributors
Author / Creator
DiGiandomenico, Antonio
Keller, Ashley E.
Smith, Trevor R. F.
Park, Daniel H.
Ramos, Stephanie
Schultheis, Katherine
Elliott, Sarah T. C.
Mendoza, Janess
Broderick, Kate E.
Wise, Megan C.
Yan, Jian
Jiang, Jingjing
Flingai, Seleeke
Khan, Amir S.
Muthumani, Kar
Humeau, Laurent
Cheng, Lily I.
Wachter-Rosati, Leslie
Stover, C. Kendall
Sardesai, Niranjan Y.
Weiner, David B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5cc6f71f1078455d97d037b4f8457a6b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5cc6f71f1078455d97d037b4f8457a6b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00576-7
