Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-in...
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. However, the role of Lef in αPD1-induced cardiotoxicity remains unclear. Here, we report that Lef treat...
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Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_5cf7adda13d84e3abd4019848f9d9941
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5cf7adda13d84e3abd4019848f9d9941
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58107-8
