FAK signalling controls insulin sensitivity through regulation of adipocyte survival
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Focal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth and survival of tumours. Here we show that FAK protein levels are increased in adipose tissue of insulin-resistant obese mice and humans. Disruption of adipocyte
FAK
in mice or in 3T3 L1 cells decreases adipocyte survival. Adipocyte-specific
FAK...
Alternative Titles
Full title
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
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TN_cdi_doaj_primary_oai_doaj_org_article_5d165920dc0744d7a47a01caacc2dd90
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d165920dc0744d7a47a01caacc2dd90
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14360
