PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
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Author / Creator
Liang, Ji , Cao, Ruixiu , Zhang, Yajuan , Xia, Yan , Zheng, Yanhua , Li, Xinjian , Wang, Liwei , Yang, Weiwei and Lu, Zhimin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation results in c-Src-mediated Cdc25A phosphorylation...
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Full title
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5d3275252c584869916d164239c89daf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d3275252c584869916d164239c89daf
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12431
