Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation...
Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial
About this item
Full title
Author / Creator
Lim, Endry H. T. , Vlaar, Alexander P. J. , Bos, Lieuwe D. J. , van Vught, Lonneke A. , Boer, Anita M. Tuip-de , Dujardin, Romein W. G. , Habel, Maria , Xu, Zhongli , Brouwer, Matthijs C. , van de Beek, Diederik , de Bruin, Sanne , van Agtmael, Michiel , Algera, Anne Geke , Appelman, Brent , van Baarle, Floor , Beudel, Martijn , Bogaard, Harm Jan , Bomers, Marije , Bonta, Peter , Botta, Michela , de Brabander, Justin , Bree, Godelieve , Bugiani, Marianna , Bulle, Esther , Chouchane, Osoul , Cloherty, Alex , Buis, David T. P. , de Rotte, Maurits C. F. J. , Dijkstra, Mirjam , Dongelmans, Dave A. , Elbers, Paul , Fleuren, Lucas , Geerlings, Suzanne , Geijtenbeek, Theo , Girbes, Armand , Goorhuis, Bram , Grobusch, Martin P. , Hagens, Laura , Hamann, Jorg , Harris, Vanessa , Hemke, Robert , Hermans, Sabine M. , Heunks, Leo , Hollmann, Markus , Horn, Janneke , Hovius, Joppe W. , de Jong, Menno D. , Koning, Rutger , van Mourik, Niels , Nellen, Jeannine , Nossent, Esther J. , Paulus, Frederique , Peters, Edgar , Piña-Fuentes, Dan A. I. , van der Poll, Tom , Preckel, Bennedikt , Prins, Jan M. , Raasveld, Jorinde , Reijnders, Tom , Schinkel, Michiel , Schrauwen, Femke A. P. , Schultz, Marcus J. , Schuurman, Alex , Schuurmans, Jaap , Sigaloff, Kim , Slim, Marleen A. , Smeele, Patrick , Smit, Marry , Stijnis, Cornelis S. , Stilma, Willemke , Teunissen, Charlotte , Thoral, Patrick , Tsonas, Anissa M. , Tuinman, Pieter R. , van der Valk, Marc , Veelo, Denise , Volleman, Carolien , de Vries, Heder , van Vugt, Michèle , Wouters, Dorien , Zwinderman, Aeilko H. , Wiersinga, W. Joost , the Amsterdam UMC COVID-19 Biobank Investigators and Amsterdam UMC COVID-19 Biobank Investigators
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
We recently reported in the phase 3 PANAMO trial that selectively blocking complement 5a (C5a) with vilobelimab led to improved survival in critically ill COVID-19 patients. C5a is an important contributor to the innate immune system and can also activate the coagulation system. High C5a levels have been reported in severely ill COVID-19 patients a...
Alternative Titles
Full title
Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial
Authors, Artists and Contributors
Author / Creator
Vlaar, Alexander P. J.
Bos, Lieuwe D. J.
van Vught, Lonneke A.
Boer, Anita M. Tuip-de
Dujardin, Romein W. G.
Habel, Maria
Xu, Zhongli
Brouwer, Matthijs C.
van de Beek, Diederik
de Bruin, Sanne
van Agtmael, Michiel
Algera, Anne Geke
Appelman, Brent
van Baarle, Floor
Beudel, Martijn
Bogaard, Harm Jan
Bomers, Marije
Bonta, Peter
Botta, Michela
de Brabander, Justin
Bree, Godelieve
Bugiani, Marianna
Bulle, Esther
Chouchane, Osoul
Cloherty, Alex
Buis, David T. P.
de Rotte, Maurits C. F. J.
Dijkstra, Mirjam
Dongelmans, Dave A.
Elbers, Paul
Fleuren, Lucas
Geerlings, Suzanne
Geijtenbeek, Theo
Girbes, Armand
Goorhuis, Bram
Grobusch, Martin P.
Hagens, Laura
Hamann, Jorg
Harris, Vanessa
Hemke, Robert
Hermans, Sabine M.
Heunks, Leo
Hollmann, Markus
Horn, Janneke
Hovius, Joppe W.
de Jong, Menno D.
Koning, Rutger
van Mourik, Niels
Nellen, Jeannine
Nossent, Esther J.
Paulus, Frederique
Peters, Edgar
Piña-Fuentes, Dan A. I.
van der Poll, Tom
Preckel, Bennedikt
Prins, Jan M.
Raasveld, Jorinde
Reijnders, Tom
Schinkel, Michiel
Schrauwen, Femke A. P.
Schultz, Marcus J.
Schuurman, Alex
Schuurmans, Jaap
Sigaloff, Kim
Slim, Marleen A.
Smeele, Patrick
Smit, Marry
Stijnis, Cornelis S.
Stilma, Willemke
Teunissen, Charlotte
Thoral, Patrick
Tsonas, Anissa M.
Tuinman, Pieter R.
van der Valk, Marc
Veelo, Denise
Volleman, Carolien
de Vries, Heder
van Vugt, Michèle
Wouters, Dorien
Zwinderman, Aeilko H.
Wiersinga, W. Joost
the Amsterdam UMC COVID-19 Biobank Investigators
Amsterdam UMC COVID-19 Biobank Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5d4d30322d4340d189e888acf0f705da
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d4d30322d4340d189e888acf0f705da
Other Identifiers
ISSN
1465-993X,1465-9921
E-ISSN
1465-993X
DOI
10.1186/s12931-022-02278-1
