Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles
Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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APOBEC3 (A3) proteins are host-encoded deoxycytidine deaminases that provide an innate immune barrier to retroviral infection, notably against HIV-1. Low levels of deamination are believed to contribute to the genetic evolution of HIV-1, while intense catalytic activity of these proteins can induce catastrophic hypermutation in proviral DNA leading...
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Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles
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TN_cdi_doaj_primary_oai_doaj_org_article_5d4fac7ee2454ce3a9f9906f54abe8e0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d4fac7ee2454ce3a9f9906f54abe8e0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35379-y
