PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy
PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy
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Author / Creator
He, Qiongyao , He, Wu , Ren, Yanlin , Wu, Wenbin , Dong, Hui , Yuan, Gang , Ren, Huihui , Wang, Xinwei , Lu, Fuer and Wang, Dingkun
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Ferroptosis, an iron-dependent form of programmed cell death, is closely associated with tubular damage in diabetic nephropathy (DN). Glutathione peroxidase 4 (GPX4) is an important anti-oxidant enzyme, and plays a crucial role in protecting against ferroptosis. However, the regulatory mechanism of GPX4 expression levels in renal tubular epithelial...
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Full title
PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy
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TN_cdi_doaj_primary_oai_doaj_org_article_5d5105230be243f3a5cef6ae63b677a0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d5105230be243f3a5cef6ae63b677a0
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ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-025-02253-5
