Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC
high
but not MYC
low
cells by a CRISPR/Cas9 genome-wide screen in a MYC-conditional HCC model. Our screen uncovers novel MYC synthe...
Alternative Titles
Full title
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
Authors, Artists and Contributors
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TN_cdi_doaj_primary_oai_doaj_org_article_5d5960aaff2349adbf61a3465136928e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d5960aaff2349adbf61a3465136928e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45128-y
