An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
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Author / Creator
Lees, Joshua A. , Dias, João M. , Rajamohan, Francis , Fortin, Jean-Philippe , O’Connor, Rebecca , Kong, Jimmy X. , Hughes, Emily A. G. , Fisher, Ethan L. , Tuttle, Jamison B. , Lovett, Gabrielle , Kormos, Bethany L. , Unwalla, Rayomand J. , Zhang, Lei , Dechert Schmitt, Anne-Marie , Zhou, Dahui , Moran, Michael , Stevens, Kimberly A. , Fennell, Kimberly F. , Varghese, Alison E. , Maxwell, Andrew , Cote, Emmaline E. , Zhang, Yuan and Han, Seungil
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
GPR61 is an orphan GPCR related to biogenic amine receptors. Its association with phenotypes relating to appetite makes it of interest as a druggable target to treat disorders of metabolism and body weight, such as obesity and cachexia. To date, the lack of structural information or a known biological ligand or tool compound has hindered comprehens...
Alternative Titles
Full title
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
Authors, Artists and Contributors
Author / Creator
Dias, João M.
Rajamohan, Francis
Fortin, Jean-Philippe
O’Connor, Rebecca
Kong, Jimmy X.
Hughes, Emily A. G.
Fisher, Ethan L.
Tuttle, Jamison B.
Lovett, Gabrielle
Kormos, Bethany L.
Unwalla, Rayomand J.
Zhang, Lei
Dechert Schmitt, Anne-Marie
Zhou, Dahui
Moran, Michael
Stevens, Kimberly A.
Fennell, Kimberly F.
Varghese, Alison E.
Maxwell, Andrew
Cote, Emmaline E.
Zhang, Yuan
Han, Seungil
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5d8246b6d9824727b8ad761786a5eac1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d8246b6d9824727b8ad761786a5eac1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41646-3
