Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
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Author / Creator
Sun, Lianhui , Zhang, Yuan , Yang, Boyu , Sun, Sijun , Zhang, Pengshan , Luo, Zai , Feng, Tingting , Cui, Zelin , Zhu, Ting , Li, Yuming , Qiu, Zhengjun , Fan, Guangjian and Huang, Chen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown. Here, we show that copper content is significantly elevated in gastric cancer (GC), especially in mali...
Alternative Titles
Full title
Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5db9a4a545be44c3b1fa6184874118e4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5db9a4a545be44c3b1fa6184874118e4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42025-8
