Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrates, and inhibitors. Here we report the conformation of an oxidized state with an intramolecular disulfide bond...
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Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
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TN_cdi_doaj_primary_oai_doaj_org_article_5db9dbcc41a443aea05c543a36e1e73e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5db9dbcc41a443aea05c543a36e1e73e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43763-5
