Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
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Author / Creator
Aydin, Sidar , Pareja, Javier , Schallenberg, Vivianne M. , Klopstein, Armelle , Gruber, Thomas , Page, Nicolas , Bouillet, Elisa , Blanchard, Nicolas , Liblau, Roland , Körbelin, Jakob , Schwaninger, Markus , Johnson, Aaron J. , Schenk, Mirjam , Deutsch, Urban , Merkler, Doron and Engelhardt, Britta
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8
+
T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8
+
T cell entry into the CNS. Here, we show that brain endo...
Alternative Titles
Full title
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
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TN_cdi_doaj_primary_oai_doaj_org_article_5dc449b410d94851b2e874ed632dc890
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5dc449b410d94851b2e874ed632dc890
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38703-2
