Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor def...
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of both upper and lower motor neurons, leading to progressive paralysis. Both genetic alterations and epigenetic modifications contribute to neuronal dysfunction in the pathogenesis of ALS. However, the mechanism behind genetic mutations in the non-c...
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Full title
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_5dcd6fb38273477e8a9538fac4c6aa10
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5dcd6fb38273477e8a9538fac4c6aa10
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-024-00792-y
