Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in...
Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and is a major component of synovial fluid. PRG4 is a ligand of the CD44 receptor. Our object...
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Full title
Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium
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TN_cdi_doaj_primary_oai_doaj_org_article_5dd97d15ec474874a9a0dbc67ead04e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5dd97d15ec474874a9a0dbc67ead04e1
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ISSN
1478-6362,1478-6354
E-ISSN
1478-6362
DOI
10.1186/s13075-020-02207-x
