Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate
Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate
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Author / Creator
Yan, Qiaoli , Lu, Xiaogang , Zhang, Zixuan , Jin, Qian , Gao, Runli , Li, Liqin and Wang, Hongmei
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Novel nereistoxin derivatives containing phosphonate were synthesized and characterized via 31P, 1H and 13C NMR and HRMS. The anticholinesterase activity of the synthesized compounds was evaluated on human acetylcholinesterase (AChE) using the in vitro Ellman method. Most of the compounds exhibited good inhibition of acetylcholinesterase. All of th...
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Full title
Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5e44db2197934922bc64301bc0ce2634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5e44db2197934922bc64301bc0ce2634
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules28124846
