Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na
+
/H
+
-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated by the Ser/Thr phosphatase calcineurin (CN). NHE1 activity is increased by phosphorylation of NHE1 residue T779...
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Full title
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
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TN_cdi_doaj_primary_oai_doaj_org_article_5e565aa376cd44bab46f43a617043caa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5e565aa376cd44bab46f43a617043caa
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11391-7
