Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Patched regulates lipid homeostasis by controlling cellular cholesterol levels
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. While the PTCH homolog PTC-3 is essential in
C. elegans
, worms lack SMO, providing an excellent model to pro...
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Full title
Patched regulates lipid homeostasis by controlling cellular cholesterol levels
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TN_cdi_doaj_primary_oai_doaj_org_article_5e7eddb79b0041a6b55bc4fe25d73484
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5e7eddb79b0041a6b55bc4fe25d73484
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24995-9
