A mathematical model of tumor regression and recurrence after therapeutic oncogene inactivation
A mathematical model of tumor regression and recurrence after therapeutic oncogene inactivation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The targeted inactivation of individual oncogenes can elicit regression of cancers through a phenomenon called oncogene addiction. Oncogene addiction is mediated by cell-autonomous and immune-dependent mechanisms. Therapeutic resistance to oncogene inactivation leads to recurrence but can be counteracted by immune surveillance. Predicting the timin...
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Full title
A mathematical model of tumor regression and recurrence after therapeutic oncogene inactivation
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TN_cdi_doaj_primary_oai_doaj_org_article_5eaa4c551c6b436ebaa97bfaaabc2d0e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5eaa4c551c6b436ebaa97bfaaabc2d0e
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-78947-2
