IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of c...
IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation
About this item
Full title
Author / Creator
Kato, Taigo , Matsubara, Nobuaki , Shiota, Masaki , Eto, Masatoshi , Osawa, Takahiro , Abe, Takashige , Shinohara, Nobuo , Yasumizu, Yota , Tanaka, Nobuyuki , Oya, Mototsugu , Nishimoto, Koshiro , Hayashi, Takuji , Nakayama, Masashi , Kojima, Takahiro , Namikawa, Kenjiro , Fujisawa, Takao , Okano, Susumu , Hida, Eisuke , Nakamura, Yoshiaki , Bando, Hideaki , Yoshino, Takayuki and Nonomura, Norio
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Previous clinical trials have demonstrated the potential efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) in patients with cancer involving homologous recombination repair (HRR) gene-mutation. Moreover, HRR gene-mutated cancers are effectively treated with immune checkpoint inhibitors (ICIs) with the increase in tumor mutation bu...
Alternative Titles
Full title
IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation
Authors, Artists and Contributors
Author / Creator
Matsubara, Nobuaki
Shiota, Masaki
Eto, Masatoshi
Osawa, Takahiro
Abe, Takashige
Shinohara, Nobuo
Yasumizu, Yota
Tanaka, Nobuyuki
Oya, Mototsugu
Nishimoto, Koshiro
Hayashi, Takuji
Nakayama, Masashi
Kojima, Takahiro
Namikawa, Kenjiro
Fujisawa, Takao
Okano, Susumu
Hida, Eisuke
Nakamura, Yoshiaki
Bando, Hideaki
Yoshino, Takayuki
Nonomura, Norio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5f0dc8735dd54b21bcb309ee64c3e011
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f0dc8735dd54b21bcb309ee64c3e011
Other Identifiers
ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-022-10398-6
