Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynam...
Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons
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Author / Creator
Zhao, Yujun , Tian, Jing , Sui, Shaomei , Yuan, Xiaodong , Chen, Hao , Qu, Chuanqiang , Du, Yifeng , Guo, Lan and Du, Heng
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Succinyl Coenzyme A synthetase (SCS) is a key mitochondrial enzyme. Defected SCS ADP-forming β subunit (SCS A-β) is linked to lethal infantile Leigh or leigh-like syndrome. However, the impacts of SCS A-β deficiency on mitochondria specifically in neurons have not yet been comprehensively investigated. Here, by down-regulating the expression levels...
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Full title
Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_5f4d68f35beb4d518f4f69fc1f40df70
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f4d68f35beb4d518f4f69fc1f40df70
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-05168-5
