Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerabil...
Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
About this item
Full title
Author / Creator
Iwai, Kenichi , Yaguchi, Masahiro , Nishimura, Kazuho , Yamamoto, Yukiko , Tamura, Toshiya , Nakata, Daisuke , Dairiki, Ryo , Kawakita, Yoichi , Mizojiri, Ryo , Ito, Yoshiteru , Asano, Moriteru , Maezaki, Hironobu , Nakayama, Yusuke , Kaishima, Misato , Hayashi, Kozo , Teratani, Mika , Miyakawa, Shuichi , Iwatani, Misa , Miyamoto, Maki , Klein, Michael G , Lane, Wes , Snell, Gyorgy , Tjhen, Richard , He, Xingyue , Pulukuri, Sai and Nomura, Toshiyuki
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent inhibitor of Cdc2‐like kinases (CLKs), evolutionally conserved kinases that facilitate exon recognition in the splic...
Alternative Titles
Full title
Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
Authors, Artists and Contributors
Author / Creator
Yaguchi, Masahiro
Nishimura, Kazuho
Yamamoto, Yukiko
Tamura, Toshiya
Nakata, Daisuke
Dairiki, Ryo
Kawakita, Yoichi
Mizojiri, Ryo
Ito, Yoshiteru
Asano, Moriteru
Maezaki, Hironobu
Nakayama, Yusuke
Kaishima, Misato
Hayashi, Kozo
Teratani, Mika
Miyakawa, Shuichi
Iwatani, Misa
Miyamoto, Maki
Klein, Michael G
Lane, Wes
Snell, Gyorgy
Tjhen, Richard
He, Xingyue
Pulukuri, Sai
Nomura, Toshiyuki
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5f979a579b0246ad90c5cfcded6e406d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5f979a579b0246ad90c5cfcded6e406d
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201708289
