New somatic BRAF splicing mutation in Langerhans cell histiocytosis
New somatic BRAF splicing mutation in Langerhans cell histiocytosis
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF
and MAP2K1 mutations by whole exome sequencing. We identified a new somatic BRAF splicing mutation in 2 cases. Both cases were childhood single system...
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Full title
New somatic BRAF splicing mutation in Langerhans cell histiocytosis
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TN_cdi_doaj_primary_oai_doaj_org_article_5fcf34ebe17645f294020d25a4adfd9c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5fcf34ebe17645f294020d25a4adfd9c
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-017-0690-z
