LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young...
LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration
About this item
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Author / Creator
van Tilburg, Cornelis M. , Kilburn, Lindsay B. , Perreault, Sébastien , Schmidt, Rene , Azizi, Amedeo A. , Cruz-Martínez, Ofelia , Zápotocký, Michal , Scheinemann, Katrin , Meeteren, Antoinette Y. N. Schouten-van , Sehested, Astrid , Opocher, Enrico , Driever, Pablo Hernáiz , Avula, Shivaram , Ziegler, David S. , Capper, David , Koch, Arend , Sahm, Felix , Qiu, Jiaheng , Tsao, Li-Pen , Blackman, Samuel C. , Manley, Peter , Milde, Till , Witt, Ruth , Jones, David T. W. , Hargrave, Darren and Witt, Olaf
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and BRAF V600E mutations. This makes pLGG an ideal candidate for MAPK pathway-targeted treatments. The type I BRAF inhibitor...
Alternative Titles
Full title
LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration
Authors, Artists and Contributors
Author / Creator
Kilburn, Lindsay B.
Perreault, Sébastien
Schmidt, Rene
Azizi, Amedeo A.
Cruz-Martínez, Ofelia
Zápotocký, Michal
Scheinemann, Katrin
Meeteren, Antoinette Y. N. Schouten-van
Sehested, Astrid
Opocher, Enrico
Driever, Pablo Hernáiz
Avula, Shivaram
Ziegler, David S.
Capper, David
Koch, Arend
Sahm, Felix
Qiu, Jiaheng
Tsao, Li-Pen
Blackman, Samuel C.
Manley, Peter
Milde, Till
Witt, Ruth
Jones, David T. W.
Hargrave, Darren
Witt, Olaf
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6042d3662e6a4c2d9fc8d41531bad22c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6042d3662e6a4c2d9fc8d41531bad22c
Other Identifiers
ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-024-11820-x
