Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immun...
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
About this item
Full title
Author / Creator
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and require CSF1R signaling for their maintenance. Pexidartinib (PLX3397, PLX), a small molecule inhibitor of the CSF1R, has been shown to effecti...
Alternative Titles
Full title
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6135ff905552462dab4b03bafd35cb55
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6135ff905552462dab4b03bafd35cb55
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02924-5
