Log in to save to my catalogue

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in...

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6187b06c5a3643429f9e40f41b6a7bb5

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

About this item

Full title

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-05, Vol.13 (1), p.3022-17, Article 3022

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with
BRCA
mutations. However, the impact of this class of inhibitors in patients with advanced
BRCA
-mutant breast cancer is relatively modest. Using a syngeneic genetically-engineered mouse model of breast tumor driven by
Brca1
def...

Alternative Titles

Full title

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6187b06c5a3643429f9e40f41b6a7bb5

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6187b06c5a3643429f9e40f41b6a7bb5

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-30568-1

How to access this item