STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in...
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
About this item
Full title
Author / Creator
Wang, Qiwei , Bergholz, Johann S. , Ding, Liya , Lin, Ziying , Kabraji, Sheheryar K. , Hughes, Melissa E. , He, Xiadi , Xie, Shaozhen , Jiang, Tao , Wang, Weihua , Zoeller, Jason J. , Kim, Hye-Jung , Roberts, Thomas M. , Konstantinopoulos, Panagiotis A. , Matulonis, Ursula A. , Dillon, Deborah A. , Winer, Eric P. , Lin, Nancy U. and Zhao, Jean J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with
BRCA
mutations. However, the impact of this class of inhibitors in patients with advanced
BRCA
-mutant breast cancer is relatively modest. Using a syngeneic genetically-engineered mouse model of breast tumor driven by
Brca1
def...
Alternative Titles
Full title
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
Authors, Artists and Contributors
Author / Creator
Bergholz, Johann S.
Ding, Liya
Lin, Ziying
Kabraji, Sheheryar K.
Hughes, Melissa E.
He, Xiadi
Xie, Shaozhen
Jiang, Tao
Wang, Weihua
Zoeller, Jason J.
Kim, Hye-Jung
Roberts, Thomas M.
Konstantinopoulos, Panagiotis A.
Matulonis, Ursula A.
Dillon, Deborah A.
Winer, Eric P.
Lin, Nancy U.
Zhao, Jean J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6187b06c5a3643429f9e40f41b6a7bb5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6187b06c5a3643429f9e40f41b6a7bb5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30568-1