ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replicatio...
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Oncogene-induced replicative stress (RS) drives tumor progression by disrupting genome stability, primarily through transcription-replication conflicts (TRCs), which promote R-loop accumulation and trigger the DNA damage response (DDR). In this study, we investigate the role of chromatin regulators in exacerbating TRCs and R-loop accumulation in ca...
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Full title
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_61acca69a6e141578a2522cb461c3afc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_61acca69a6e141578a2522cb461c3afc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59804-0
