Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colo...
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Genotoxic colibactin-producing
pks
+
Escherichia coli
induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected in human CRC, suggesting a causal link. Here, we investigate its transformation potential using organoids from...
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Full title
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
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TN_cdi_doaj_primary_oai_doaj_org_article_6216b08bac074ebf879284a8ec39ba76
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6216b08bac074ebf879284a8ec39ba76
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21162-y
