Plk1 overexpression induces chromosomal instability and suppresses tumor development
Plk1 overexpression induces chromosomal instability and suppresses tumor development
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse model we report here that Plk1 overexpression results in abnormal chromosome segregation and cytoki...
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Plk1 overexpression induces chromosomal instability and suppresses tumor development
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TN_cdi_doaj_primary_oai_doaj_org_article_624e442f805148c5bac60f63e764f010
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_624e442f805148c5bac60f63e764f010
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05429-5
