Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macro...
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
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Author / Creator
Wang, Chenyao , Wang, Huafei , Zhang, Deyi , Luo, Wenwen , Liu, Ruilong , Xu, Daqian , Diao, Lei , Liao, Lujian and Liu, Zhixue
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown. Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome–lysosome fusion. PKCα phosphorylates...
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Full title
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
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TN_cdi_doaj_primary_oai_doaj_org_article_62852709b9784c59a2fbefdf94a827c2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62852709b9784c59a2fbefdf94a827c2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05449-1
