Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical or...
Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Duplication or deficiency of the X‐linked
MECP2
gene reliably produces profound neurodevelopmental impairment.
MECP2
mutations are almost universally responsible for Rett syndrome (RTT), and particular mutations and cellular mosaicism of
MECP2
may underlie the spectrum of RTT symptomatic severity. No clinically approved treatments...
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Full title
Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
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TN_cdi_doaj_primary_oai_doaj_org_article_62a5f92686b74314967f1f52b82ce189
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62a5f92686b74314967f1f52b82ce189
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202012523
