Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK...
Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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(1) Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates the circulating cholesterol level. In this field, we discovered natural peptides derived from lupin that showed PCSK9 inhibitory activity. Among these, the most active peptide, k...
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Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity
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TN_cdi_doaj_primary_oai_doaj_org_article_62b0a2eea54147f385d3db13613ad656
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62b0a2eea54147f385d3db13613ad656
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ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics14030665
