Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
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Switzerland: Molecular Diversity Preservation International
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Language
English
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Switzerland: Molecular Diversity Preservation International
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Contents
A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica. Based on computer modeling and the X-ray structure of the A. californica AChBP complex with the PnIA[A10L...
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Full title
Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
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TN_cdi_doaj_primary_oai_doaj_org_article_62ccfb67bfb3480fae5da1bb92708fbd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_62ccfb67bfb3480fae5da1bb92708fbd
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ISSN
1660-3397
E-ISSN
1660-3397
DOI
10.3390/md9101698
